{"id":151526,"date":"2025-02-11T11:29:14","date_gmt":"2025-02-11T17:29:14","guid":{"rendered":"https:\/\/www.uv.mx\/prensa\/?p=151526"},"modified":"2025-02-11T12:40:14","modified_gmt":"2025-02-11T18:40:14","slug":"investigador-abordo-relacion-de-hierro-e-hipoxia-con-la-epilepsia","status":"publish","type":"post","link":"https:\/\/www.uv.mx\/prensa\/general\/investigador-abordo-relacion-de-hierro-e-hipoxia-con-la-epilepsia\/","title":{"rendered":"Investigador abord\u00f3 relaci\u00f3n de hierro e hipoxia con la epilepsia"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"1\" data-list-defn-props=\"{&quot;335551671&quot;:1088,&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"1088\" data-aria-level=\"1\"><i><span data-contrast=\"auto\">Jer\u00f3nimo Auzmendi, investigador argentino, ofreci\u00f3 la conferencia \u201cFerroptosis y epilepsia, \u00bfqu\u00e9 fue primero?\u201d<\/span><\/i><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335557856&quot;:16777215,&quot;335559738&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"1\" data-list-defn-props=\"{&quot;335551671&quot;:1088,&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"1089\" data-aria-level=\"1\"><i><span data-contrast=\"auto\">A invitaci\u00f3n del Instituto de Investigaciones Cerebrales (Iice) de la UV, y el Instituto de Neurobiolog\u00eda de la UNAM<\/span><\/i><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335557856&quot;:16777215,&quot;335559738&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"1\" data-list-defn-props=\"{&quot;335551671&quot;:1088,&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"1090\" data-aria-level=\"1\"><i><span data-contrast=\"auto\">El Iice present\u00f3 el n\u00famero especial de la revista <\/span><\/i>eNeurobiolog\u00eda<\/li>\n<\/ul>\n<div id=\"attachment_151515\" style=\"width: 732px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-151515\" class=\"size-full wp-image-151515\" src=\"https:\/\/www.uv.mx\/prensa\/files\/2025\/02\/100225-COUTTOLENC-Hierro-e-hipoxia-1.jpg\" alt=\"\" width=\"722\" height=\"395\" srcset=\"https:\/\/www.uv.mx\/prensa\/files\/2025\/02\/100225-COUTTOLENC-Hierro-e-hipoxia-1.jpg 722w, https:\/\/www.uv.mx\/prensa\/files\/2025\/02\/100225-COUTTOLENC-Hierro-e-hipoxia-1-300x164.jpg 300w\" sizes=\"auto, (max-width: 722px) 100vw, 722px\" \/><p id=\"caption-attachment-151515\" class=\"wp-caption-text\">El investigador argentino Jer\u00f3nimo Auzmendi ofreci\u00f3 conferencia sobre hierro e hopoxia, y su relaci\u00f3n con la epilepsia<\/p><\/div>\n<p>&nbsp;<\/p>\n<p><b><i><span data-contrast=\"auto\">Jos\u00e9 Luis Couttolenc Soto<\/span><\/i><\/b><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335557856&quot;:16777215,&quot;335559738&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><b><i><span data-contrast=\"auto\">Fotos: Omar Portilla palacios<\/span><\/i><\/b><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335557856&quot;:16777215,&quot;335559738&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><b><i><span data-contrast=\"auto\">11\/02\/2025, Xalapa, Ver.-<\/span><\/i><\/b> <span data-contrast=\"auto\">Con motivo del D\u00eda Internacional de la Epilepsia que se celebra el segundo lunes de febrero de cada a\u00f1o,\u00a0<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335557856&quot;:16777215,&quot;335559738&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\"> \u00a0<\/span><span data-contrast=\"auto\">Jer\u00f3nimo Auzmendi, profesor investigador de la Facultad de Farmacia y Bioqu\u00edmica de la Universidad de Buenos Aires, Argentina, ofreci\u00f3 la videoconferencia \u201cFerroptosis y epilepsia, \u00bfqu\u00e9 fue primero?\u201d<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335557856&quot;:16777215,&quot;335559738&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">A invitaci\u00f3n del Instituto de Investigaciones Cerebrales (<\/span><i><span data-contrast=\"auto\">Iice<\/span><\/i><span data-contrast=\"auto\">) de la Universidad Veracruzana (UV) y el Instituto de Neurobiolog\u00eda de la Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), el cient\u00edfico detall\u00f3 en su ponencia que el hierro y la hipoxia representan una combinaci\u00f3n de caminos sumamente relacionados con la epilepsia.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335557856&quot;:16777215,&quot;335559731&quot;:708,&quot;335559738&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Jer\u00f3nimo Auzmendi, cuyo trabajo est\u00e1 centrado en los mecanismos fisiopatol\u00f3gicos de la epilepsia y su relaci\u00f3n con las rutas moleculares de respuesta a la hepcidina, explic\u00f3 que la hipoxia activa la hematopoyesis dando paso a la formaci\u00f3n de nuevos gl\u00f3bulos rojos. <\/span> <span data-contrast=\"auto\">Defini\u00f3 a la ferroptosis como un tipo de muerte celular caracterizada por la producci\u00f3n de peroxidaci\u00f3n lip\u00eddica, que se presenta cuando hay un aumento de hierro en las c\u00e9lulas; a este proceso se le relaciona con el desarrollo de Parkinson, Alzheimer, c\u00e1ncer, enfermedades cardiovasculares y renales.<\/span><\/p>\n<p>&nbsp;<\/p>\n<div id=\"attachment_151514\" style=\"width: 732px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-151514\" class=\"size-full wp-image-151514\" src=\"https:\/\/www.uv.mx\/prensa\/files\/2025\/02\/100225-COUTTOLENC-Hierro-e-hipoxia-2.jpg\" alt=\"\" width=\"722\" height=\"427\" srcset=\"https:\/\/www.uv.mx\/prensa\/files\/2025\/02\/100225-COUTTOLENC-Hierro-e-hipoxia-2.jpg 722w, https:\/\/www.uv.mx\/prensa\/files\/2025\/02\/100225-COUTTOLENC-Hierro-e-hipoxia-2-300x177.jpg 300w\" sizes=\"auto, (max-width: 722px) 100vw, 722px\" \/><p id=\"caption-attachment-151514\" class=\"wp-caption-text\">UV y UNAM conmemoraron el D\u00eda Internacional de la Epilepsia, que se efect\u00faa anualmente el segundo lunes de febrero<\/p><\/div>\n<p>&nbsp;<\/p>\n<p><span data-contrast=\"auto\">Lo anterior se registra por la producci\u00f3n de radicales libres apto para sobrepasar la capacidad buffer de las c\u00e9lulas, es decir, superan los sistemas de glutati\u00f3n produciendo da\u00f1o a nivel lip\u00eddico, y la formaci\u00f3n de marcadores malondialdeh\u00eddo (de estr\u00e9s oxidativo) y de hydroxynonenal (componente en las c\u00e9lulas cuando se oxidan los l\u00edpidos).<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335557856&quot;:16777215,&quot;335559738&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">El investigador argentino precis\u00f3 que esto no es diferente al estr\u00e9s oxidativo que todos conocemos, excepto que en este caso la ferroptosis y la formaci\u00f3n de radicales libres est\u00e1n catalizados principalmente por hierro, provocando alteraciones en el sistema de cotransporte de glutamato.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335557856&quot;:16777215,&quot;335559731&quot;:708,&quot;335559738&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Para la investigaci\u00f3n, Jer\u00f3nimo Auzmendi y su equipo de trabajo dise\u00f1aron una t\u00e9cnica reductora que les permitiera medir el hierro intracelular asociado al complejo de ferritina, lo que result\u00f3 una tarea bastante complicada, y mostr\u00f3 gr\u00e1ficas de mediciones bioqu\u00edmicas vinculadas al hierro circulante en distintos esquemas de epilepsia.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335557856&quot;:16777215,&quot;335559731&quot;:708,&quot;335559738&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">El estudio, realizado en modelos murino, logr\u00f3 establecer que el sistema nervioso central y las crisis epil\u00e9pticas inducen ferroptosis, previa a la aparici\u00f3n de crisis espont\u00e1neas que producen seroptosis que estimula la aparici\u00f3n de cuadros epil\u00e9pticos en l\u00edneas generales.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335557856&quot;:16777215,&quot;335559738&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p>&nbsp;<\/p>\n<div id=\"attachment_151517\" style=\"width: 732px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-151517\" class=\"size-full wp-image-151517\" src=\"https:\/\/www.uv.mx\/prensa\/files\/2025\/02\/100225-COUTTOLENC-Hierro-e-hipoxia-3.jpg\" alt=\"\" width=\"722\" height=\"407\" srcset=\"https:\/\/www.uv.mx\/prensa\/files\/2025\/02\/100225-COUTTOLENC-Hierro-e-hipoxia-3.jpg 722w, https:\/\/www.uv.mx\/prensa\/files\/2025\/02\/100225-COUTTOLENC-Hierro-e-hipoxia-3-300x169.jpg 300w\" sizes=\"auto, (max-width: 722px) 100vw, 722px\" \/><p id=\"caption-attachment-151517\" class=\"wp-caption-text\">Las crisis epil\u00e9pticas producen aumento del reticulocito, con activaciones y descargas hep\u00e1ticas, dijo el investigador de la Universidad de Buenos Aires, Argentina<\/p><\/div>\n<p>&nbsp;<\/p>\n<p><span data-contrast=\"auto\">Por \u00faltimo, coment\u00f3 que las crisis epil\u00e9pticas producen un aumento de reticulocitos (gl\u00f3bulos rojos inmaduros), que significa las activaciones y descargas hep\u00e1ticas; por lo tanto, el aumento de transferrina plasm\u00e1tica libera hierro hacia el par\u00e9nquima, provocando nuevas crisis y el cuadro epil\u00e9ptico.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335557856&quot;:16777215,&quot;335559738&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><b><i><span data-contrast=\"auto\">Presentan n\u00famero especial de la revista eNeurobiolog\u00eda<\/span><\/i><\/b><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335557856&quot;:16777215,&quot;335559738&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">En la conmemoraci\u00f3n del D\u00eda Internacional de la Epilepsia, el <\/span><i><span data-contrast=\"auto\">Iice<\/span><\/i><span data-contrast=\"auto\"> present\u00f3 el n\u00famero especial de la revista <\/span><i><span data-contrast=\"auto\">eNeurobiolog\u00eda<\/span><\/i><span data-contrast=\"auto\">, que tiene por t\u00edtulo \u201cInvestigaci\u00f3n precl\u00ednica en epilepsia; diferentes visiones, mismos intereses\u201d y recopila investigadores que exploran diferentes enfoques para el estudio y tratamiento de la epilepsia.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335557856&quot;:16777215,&quot;335559738&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Aborda temas como: <\/span><span data-contrast=\"none\">Uso de biomarcadores en la epilepsia del l\u00f3bulo temporal; Alternativas terap\u00e9uticas en desarrollo como las nanomedicinas, y los avances en la investigaci\u00f3n sobre el cannabidiol como opci\u00f3n terap\u00e9utica. Se exploran temas innovadores como el potencial de la granada (<\/span><i><span data-contrast=\"none\">Punica granatum<\/span><\/i><span data-contrast=\"none\">) en el tratamiento de la epilepsia y los mecanismos fisiopatol\u00f3gicos detr\u00e1s de las crisis de ausencia en modelos animales.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335557856&quot;:16777215,&quot;335559738&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Estos estudios no solo enriquecen la comprensi\u00f3n de la epilepsia, sino que tambi\u00e9n abren puertas a nuevas posibilidades terap\u00e9uticas.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335557856&quot;:16777215,&quot;335559731&quot;:708,&quot;335559738&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<div id=\"attachment_151516\" style=\"width: 415px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-151516\" class=\"size-full wp-image-151516\" src=\"https:\/\/www.uv.mx\/prensa\/files\/2025\/02\/100225-COUTTOLENC-Hierro-e-hipoxia-4.jpg\" alt=\"\" width=\"405\" height=\"496\" srcset=\"https:\/\/www.uv.mx\/prensa\/files\/2025\/02\/100225-COUTTOLENC-Hierro-e-hipoxia-4.jpg 405w, https:\/\/www.uv.mx\/prensa\/files\/2025\/02\/100225-COUTTOLENC-Hierro-e-hipoxia-4-245x300.jpg 245w\" sizes=\"auto, (max-width: 405px) 100vw, 405px\" \/><p id=\"caption-attachment-151516\" class=\"wp-caption-text\">El <em>Iice<\/em> de la UV present\u00f3 el n\u00famero especial de la revista <em>eNeurobiolog\u00eda<\/em><\/p><\/div>\n<p><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335557856&quot;:16777215,&quot;335559738&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Con evento acad\u00e9mico, el Instituto de Investigaciones Cerebrales UV conmemor\u00f3 el D\u00eda Internacional de la Epilepsia <\/p>\n","protected":false},"author":1810,"featured_media":151513,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[45,47,1,61],"tags":[21578,21577,21583,21586,10529,1631,21587,21574,21576,21581,21386,21579,21575,4162,21580,21584,6462,6888,21582,1644,21585],"class_list":["post-151526","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ciencia","category-eventos","category-general","category-banner","tag-que-fue-primero","tag-ferroptosis-y-epilepsia","tag-investigacion-preclinica-en-epilepsia-diferentes-visiones","tag-alternativas-terapeuticas-en-desarrollo-como-las-nanomedicinas","tag-alzheimer","tag-argentina","tag-cannabidiol-como-opcion-terapeutica","tag-dia-internacional-de-la-epilepsia","tag-facultad-de-farmacia-y-bioquimica","tag-globulos-rojos","tag-instituto-de-investigaciones-cerebrales-iice-de-la-universidad-veracruzana-uv","tag-instituto-de-neurobiologia-de-la-universidad-nacional-autonoma-de-mexico-unam","tag-jeronimo-auzmendi","tag-jose-luis-couttolenc-soto","tag-mecanismos-fisiopatologicos-de-la-epilepsia","tag-mismos-intereses","tag-omar-portilla-palacios","tag-parkinson","tag-revista-eneurobiologia","tag-universidad-de-buenos-aires","tag-uso-de-biomarcadores-en-la-epilepsia-del-lobulo-temporal"],"_links":{"self":[{"href":"https:\/\/www.uv.mx\/prensa\/wp-json\/wp\/v2\/posts\/151526","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.uv.mx\/prensa\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.uv.mx\/prensa\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.uv.mx\/prensa\/wp-json\/wp\/v2\/users\/1810"}],"replies":[{"embeddable":true,"href":"https:\/\/www.uv.mx\/prensa\/wp-json\/wp\/v2\/comments?post=151526"}],"version-history":[{"count":1,"href":"https:\/\/www.uv.mx\/prensa\/wp-json\/wp\/v2\/posts\/151526\/revisions"}],"predecessor-version":[{"id":151539,"href":"https:\/\/www.uv.mx\/prensa\/wp-json\/wp\/v2\/posts\/151526\/revisions\/151539"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.uv.mx\/prensa\/wp-json\/wp\/v2\/media\/151513"}],"wp:attachment":[{"href":"https:\/\/www.uv.mx\/prensa\/wp-json\/wp\/v2\/media?parent=151526"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.uv.mx\/prensa\/wp-json\/wp\/v2\/categories?post=151526"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.uv.mx\/prensa\/wp-json\/wp\/v2\/tags?post=151526"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}